Search on: DNA POLYMERASE I 
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Descriptor English:   DNA Polymerase I 
Descriptor Spanish:   ADN Polimerasa I 
Descriptor Portuguese:   DNA Polimerase I 
Synonyms English:   DNA-Dependent DNA Polymerase I
Klenow Fragment
DNA Polymerase alpha  
Tree Number:   D08.811.913.696.445.308.300.225
Definition English:   A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair. EC 2.7.7.7. 
History Note English:   84(77); for DNA POLYMERASE ALPHA use DNA POLYMERASE II 1982-97 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   4323 
Unique Identifier:   D004256 

Occurrence in VHL:
 

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